Congratulations to Dr. Jun Lu, member of the Yale CCEH for his recent publication in Cell Feb 2024 entitled “Cell surface RNAs control neutrophil recruitment”. Work for the study utilized Yale CCEH sponsored cores (U54DK106857)

2024-04-09

Featured Publication

RNAs localizing to the outer cell surface have been recently identified in mammalian cells, including RNAs with glycan modifications known as glycoRNAs.



Abstract

RNAs localizing to the outer cell surface have been recently identified in mammalian cells, including RNAs with glycan modifications known as glycoRNAs. However, the functional significance of cell surface RNAs and their production are poorly known. We report that cell surface RNAs are critical for neutrophil recruitment and that the mammalian homologs of the sid-1 RNA transporter are required for glycoRNA expression. Cell surface RNAs can be readily detected in murine neutrophils, the elimination of which substantially impairs neutrophil recruitment to inflammatory sites in vivo and reduces neutrophils' adhesion to and migration through endothelial cells. Neutrophil glycoRNAs are predominantly on cell surface, important for neutrophil-endothelial interactions, and can be recognized by P-selectin (Selp). Knockdown of the murine Sidt genes abolishes neutrophil glycoRNAs and functionally mimics the loss of cell surface RNAs. Our data demonstrate the biological importance of cell surface glycoRNAs and highlight a noncanonical dimension of RNA-mediated cellular functions.

 

For details see the full article

 https://pubmed.ncbi.nlm.nih.gov/38262409/

 


 

Authors left to right – Wenwen Tang, Dianqing Wu, Jun Lu, Ningning Zhang

RNA (Green) on the surface of Neutrophils (Blue – nucleus)


Publication: 2024-04-09