Careers


Postdoctoral Position Available at the National Institutes of Health

Postdoctoral position available to study the distribution and utilization of iron cofactors within mammalian cells and tissues. Iron is an essential nutrient for every cell in the human body, yet it can also be a potent cellular toxin. Iron is essential because enzymes that require iron co-factors (namely, heme, iron-sulfur clusters, mononuclear and diiron centers) are involved in virtually every major metabolic process in the cell. Iron deficiency continues to be the most common nutritional deficiency in the world, especially among children and women of childbearing age, where it causes anemia and impairs neurological development and function. Although the pathogenesis of anemia in iron deficiency is well understood, other manifestations of iron deficiency are not understood at the cellular or metabolic level. Iron overload is a feature of an increasing number of human diseases, including genetic disorders such as hereditary hemochromatosis, thalassemias, and Friedreich ataxia, as well as chronic inflammatory diseases of the liver, such as hepatitis C. Hundreds of iron, zinc, copper, and manganese proteins are expressed in human cells, yet little is known about the mechanisms by which these metalloproteins acquire their native metal ligands and avoid mis-metallation. We have made significant advances in understanding the delivery of iron to iron-dependent enzymes in the cytosol.

We identified Poly rC-Binding Protein 1 (PCBP1) as an iron-binding protein that delivers iron to ferritin in human cells (Shi, et al. 2008, Science 320, 1207-10). This was the first description of a cytosolic iron chaperone – a protein that specifically binds iron ions and delivers them to target proteins through direct protein-protein interactions.  PCBP1 and its human paralogs are multifunctional adaptor proteins that also bind single-stranded DNA and RNA in a sequence-specific manner to regulate the fate of the nucleic acid. PCBP2, a human paralog of PCBP1, is independently required for the delivery of iron to ferritin. PCBP1 and PCBP2 deliver iron to additional families of target enzymes: the prolyl hydroxylases (PHDs) that regulate the degradation of hypoxia inducible factor 1 (HIF1) and deoxyhypusine hydroxylase (DOHH). Projects currently underway explore the roles of PCBPs in erythroid cell development, duodenal iron absorption, macrophage iron recycling, and the intersection of iron ion chaperones with the Fe-S cluster machinery. Mouse models of PCBP1 and PCBP2 deficiency have been developed and are revealing new functions of these proteins in maintaining iron homeostasis in mammals.

We use the tools of cell biology, genetics and biochemistry to address questions about how cells and animals use iron. The postdoctoral position is fully funded, available immediately, and open to any motivated Ph.D./M.D. with less than five years of postdoctoral experience. NIH is an equal opportunity employer.

Contact:
Caroline C. Philpott, M. D.
Chief, Genetics and Metabolism Section
Liver Diseases Branch, NIDDK, NIH                      Web: http://irp.nih.gov/pi/caroline-philpott
Bldg 10, Rm 9B-16                                                       Phone: 301-435-4018   
10 Center Drive                                                             Fax: 301-402-0491
Bethesda, MD 20892-1800                                       Email: carolinep@mail.nih.gov
 


Postdoctoral Position - Ullman Lab

I am looking for a postdoctoral fellow interested in driving a project that delves into new facets of nuclear biology. We’re interested in nuclear membrane dynamics during cell division and how these events impact the ER, as well as other aspects of cellular remodeling that occur in concert with changes to nuclear architecture. I have a strong record of trainee mentorship and lead a highly collaborative team, with interconnections both within the lab, to other labs on campus, and to key outside collaborators. We are fortunate to have great shared resources and colleagues at the Huntsman Cancer Institute. Experience in cell biology, cell imaging, and molecular techniques would provide an ideal launching pad for this postdoctoral research position. If you have these qualifications and are interested, please send a CV and statement of research interests to katie.ullman@hci.utah.edu.
 


Postdoctoral Scientist, Muschen Laboratory - Center of Molecular and Cellular Oncology, Yale University

Our group is interested in comparative analyses of normal lymphocyte development and malignant transformation towards leukemia. We cover research areas with relevance to Immunology, Hematology and Cancer Biology. Our research involves experiments with primary human leukemia cells, normal lymphocyte
development in humanized mice, leukemia and stem cell transplantation models, mouse genetics, gene editing, genetic biosensors of signal transduction, optogenetics, classical molecular and cell biology, a strong emphasis on mechanistic studies in oncogenic signal transduction. We strive to promote a culture of diversity and inclusivity for all its members, focusing on career development and innovative approaches to science.

Qualifications: PhD in cell or molecular biology, enthusiasm for science, willingness to think beyond established concepts and to try and learn new experimental and analysis tools. The lab takes a team science approach, being collaborative is important as well. Your application should include in one single PDF: CV, brief motivation statement, coordinates of three scientific mentors (references), send to markus.muschen@yale.edu Methods/Techniques: Flow cytometry, quantitative phosphoprofiling, genetic biosensors of signal transduction, optogenetics, mouse genetics, bone marrow transplantation assays,
retroviral gene delivery, whole exome sequencing and RNA-seq-analysis of clonal evolution of leukemia, pre-clinical drug testing in xenotransplantation models. Recent work of the laboratory: Over the past five years, the Müschen Laboratory established innovative conceptual frameworks for the understanding of B-cell signaling mechanisms and negative selection, some of which are summarized below:

  • We discovered regulation of energy-abundance as the central determinant of negative B-cell-selection: Hyperactivation of kinases downstream of an autoreactive B-cell receptor induces ATP-depletion and energy stress (Chen Nature 2015, Shojaee Nature Med 2016, Chan Nature 2017; Pan PNAS 2020).
  • Studying changes of energy-metabolism during B-cell transformation, we discovered that glucose carbon-flux was diverted in way that left transformed B-cells uniquely vulnerable to inhibition of PP2A, an enzyme that coordinates glycolytic flux with antioxidant protection (Xiao Cell 2018).
  • We discovered that changes in cell-size are orchestrated by BCL6 and MYC. Opposed by MYC, BCL6 decreases cell-size by transcriptionally repressing glucose-uptake in favor of autophagy (Duy Nature 2012; Geng Cancer Cell 2015; Hurtz Genes & Dev 2019).
  • Tracking mechanisms of leukemia-initiation in 1,100 patients, we discovered pathway convergence as a novel therapeutic vulnerability in B-ALL. Only mutations that converged on one central pathway promoted leukemia-progression. Genetic reactivation of divergent (suppressed) pathways engaged conflicting biochemical and transcriptional programs and subverted leukemia-development. Pharmacological pathway-reactivation to create a diverse signaling-environment represents a novel strategy to prevent B-ALL relapse and drug-resistance (Chan Nature 2020).
  • Studying biophysical mechanisms of B-cell activation, we discovered the short endosomal protein IFITM3 as central scaffold for lipid-raft assembly and surfaceexpression of rafts-associated receptors. Membrane-recruitment of IFITM3 was essential for the initiation of PI3K-signaling, antibody affinity maturation and oncogenic B-cell transformation (Lee Nature 2020).

https://medicine.yale.edu/lab/muschen/
http://www.hhmi.org/scientists/markus-muschen
 


Postdoctoral Position in MDS and Leukemia in the Yale Comprehensive Cancer Center

A postdoctoral position is available in Dr. Stephanie Halene’s laboratory at Yale University School of Medicine, to study cancer mutations and aberrations in splicing and RNA modifications in MDS and Leukemia. The Halene Lab is also studying the effect of COVID 19 on hematologic malignancies. Located in the Yale Comprehensive Cancer Center, the Halene laboratory studies RNA splicing, RNA modifications, and genomics in hematopoietic stem cell biology and in MDS and Leukemia.

We use state of the art tools and techniques, including RNA immunoprecipitation coupled with high-throughput sequencing (eCLIP), single cell sequencing, m6A CLIP,  Riboseq, RNAseq, targeted exome seq, as well as biochemistry and functional genomics in cell lines, primary mouse models, and primary patient samples and state of the art bioinformatic analyses. In collaboration with the laboratory of Dr. Richard Flavell we have developed a unique, highly efficient xenotransplantation model for the study of human hematopoiesis, MDS, and leukemia, presenting a powerful tool to study mechanism and therapeutic approaches in vivo.

Candidates with strong background in RNA biology, hematopoiesis/leukemia, genomics, mouse models, and/or molecular biology are particularly encouraged to apply. Strong bioinformatic skills are a plus. Applicants with a Ph.D. should submit curriculum vitae and names of three references to Dr. Stephanie Halene (stephanie.halene@yale.edu).  Please enter “Postdoc Position” in subject line of e-mail.

Yale University is an Affirmative Action/Equal Opportunity Employer and welcomes applications from women, persons with disabilities, protected veterans, and members of minority groups.
 


Oregon Health & Science University Postdoctural Positions Available

Postdoctoral positions in the Enns/Zhang Labs in the Department of Cell, Developmental, and Cancer Biology at Oregon Health & Science University, Portland, OR USA.

Our labs focus on identifying the molecular mechanisms by which the body senses iron and the pathways involved in maintaining iron homeostasis. Diseases that disrupt these homeostatic mechanisms include, but are not limited to hereditary hemochromatosis, infectious diseases, heart failure, cancer and hematopoietic disorders. We combine state-of-the-art approaches involving mouse models, gene therapy, mass spectrometry, advanced light microscopy and bioinformatics in a collaborative environment.

Successful candidates must have a PhD and/or MD and a published record of accomplishment. Expertise in molecular biology, cell biology, and/or protein chemistry are preferred. OHSU offers a variety of grant writing and career mentoring programs for postdoctoral fellows. Please submit a cover letter, curriculum vitae, and contact information for three references to:

Dr. Caroline Enns (ennsca@ohsu.edu)

Salary and benefits: The salary is set according to NIH guidelines. Benefits include health and dental insurance.
 


POST-DOCTORAL TRAINING POSITION AVAILABLE: Bone Marrow Spatial Transcriptomics to Enhance In Vitro Platelet Production

The Moffitt and Cantor Laboratories at Boston Children’s Hospital/Harvard Medical School (HMS) are currently accepting applications for an entry-level joint post-doctoral training position. The Moffitt lab focuses on development and utilization of in situ single-molecule imaging methods to further understand tissue architecture, developmental signaling, and novel cell type identification. The Cantor lab specializes in hematopoiesis and platelet production. This joint project will develop and apply Multiplexed Error-robust Fluorescence In Situ Hybridization (MERFISH) to the mouse and human bone marrow to further understand how megakaryocytes generate platelets in the context of their native microenvironment. This knowledge will then be applied to enhance in vitro platelet production from induced pluripotent stem cells (hIPSCs) for transfusion purposes. The candidate will also interact with the Allon Klein’s laboratory at HMS to develop and correlate scRNA-seq and in situ transcriptomic datasets. The candidate will be jointly advised by Dr. Moffitt and Dr. Cantor and will have the opportunity to learn and develop a cutting-edge spatial transcriptomics tool while substantially advancing our understanding of bone micro-environment and its critical role in the important process of platelet production and stem cell biology.

Candidates should have recently (within ~1 year) obtained a PhD or an MD/PhD degree in the fields of Computational Biology, Genomics, Molecular Biology, Cellular Biology, Biochemistry, Development, or Genetics. The candidate should have evidence of prior productive scientific work in the form of publications in peer-reviewed journals. Prior experience in computational biology, scRNAseq, and/or other “-omics” type approaches is strongly preferred. U.S. citizenship or Permanent Resident status (i.e., “Green Card” holders) is
not necessary, but is favored.

Interested candidates should send their Curriculum Vitae and a cover letter describing their background and research interests to jeffrey.moffitt@childrens.harvard.edu and alan.cantor@childrens.harvard.edu. Candidates should also arrange for two letters of recommendation, which may be requested.

Jeffrey Moffitt, PhD
Assistant Professor of Pediatrics
Program in Cellular and Molecular Medicine
Office: 617-713-8902

Alan Cantor, MD, PhD
Associate Professor of Pediatrics
Division of Pediatric Hematology/Oncology
Office: 617-919-2026

Boston Children’s Hospital is an equal opportunity employer. Women and members of under-represented
minorities are encouraged to apply


Postdoctoral Fellow/Staff Scientist at Boston Children's Hospital/Harvard Medical School

The Bauer laboratory seeks highly motivated post-doctoral research fellows and staff scientists to investigate therapeutic gene editing to address human diseases with unmet clinical needs and to explore the functional genomics of human hematopoiesis. We conduct studies ranging from technology development, target discovery, preclinical validation and first-in-human clinical application.

We have identified regulatory elements that are subject to naturally occurring disease associated genetic variation and are critical determinants of fetal hemoglobin level and hemoglobin disorder clinical severity. We have developed methodologies for high-throughput and high-resolution functional evaluation of coding and noncoding genetic elements. We have demonstrated highly efficient and specific methods for nuclease and base editing of human hematopoietic stem and progenitor cells. We use molecular genetic, biochemical, and genome editing methodologies to perturb and observe blood cells. Our studies are meant to elucidate fundamental mechanisms of gene regulatory elements in their endogenous chromosomal environment, to explore determinants of blood cell
development, homeostasis, and disease, and to define structure-function relationships of disease relevant protein complexes. A major motivation of our work is to translate findings into novel therapies for patients with blood disorders. We are advancing therapeutic gene editing from preclinical studies to first-in-human trials. Prior experience in gene editing/gene therapy, protein engineering, hematopoiesis, molecular and cell biology, genetics, biochemistry, systems biology, structural/chemical biology, and/or bioinformatics/computational biology is highly desirable. The candidate must be independent in scientific research and writing, self-motivated, ethical, team spirited, and must have exceptional laboratory, communication, organizational, and writing skills.

Interested applicants should send a CV, cover letter, statement of research interest and contact information for three references via email to Daniel Bauer, MD PhD (daniel.bauer@childrens.harvard.edu), Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, MA. Boston Children’s Hospital is one of the top pediatric research centers in the world, and a major research and teaching affiliate of Harvard Medical School. The Bauer Laboratory is also affiliated with the Dana-Farber Cancer Institute, Harvard Stem Cell Institute, and Broad Institute of Harvard and MIT.
 


Postdoc Opportunity Innate Immunity/ Inflammation at the Univ. of Utah

Job Summary

A postdoctoral position to study innate immune signaling pathways and inflammation is available immediately in the Microbiology & Immunology Division, University of Utah, Department of Pathology.

The research project is aimed at deciphering the cellular and molecular regulation of innate immunity in the context of inflammatory and autoimmune disease. In particular, we study the function of Toll-like receptors (TLRs), which are essential for pathogen recognition, but can also promote inflammatory and autoimmune diseases. In previous work we identified a key negative regulator of Toll-like receptor (TLR) signaling pathways, which is essential for protection from inflammatory diseases (Nature 2006 PMID: 16306937; PNAS 2009, PMID: 22011580; PNAS 2016, PMID: 27671649, JCI 2019, PMID: 31033479). More detailed work related to the mechanism of tissue injury revealed deregulation of myeloid cell differentiation, specifically monocyte development, as a major culprit. The goal of this project is to reveal the signaling mechanisms and genes controlling TLR biology, in particular in context with myelopoiesis and their impact on in vivo inflammation. The long-term goal is to identify novel targets for therapeutic intervention in inflammatory human diseases.     

Responsibilities
The project provides an ideal opportunity for fellows who are interested in (i) innate immunity and inflammation regulation in context of hematopoiesis/ myelopoiesis and (ii) molecular mechanisms of signal transduction, applying cutting edge protein identification/ interaction analyses, such as quantitative MS.

For more information related to the lab, the breadth of resources at the University of Utah and the stunning environment of Salt Lake City/ Utah please see: https://medicine.utah.edu/pathology/research/labs/hans-haecker/

Qualifications and Preferences
Applicants should hold a PhD and/or MD degree in Biochemistry, Biology or Immunology. The ideal candidate should have expertise in molecular biology and protein analysis and, preferably, experience with animal (mouse) in vivo experimentation. 

Work Schedule Summary
Monday – Friday with some occasional evening and weekend work.

Pay Rate Range $52,704 to $55,596

Application: To apply, please send a cover letter as well as CV including publication history and three professional references to Dr. Hans Haecker, Professor at the Microbiology & Immunology Division of the Pathology Department, University of Utah, using the following link: https://utah.peopleadmin.com/postings/106232
 


Faculty Positions in Immunology/Host Defense University of Utah School of Medicine, Salt Lake City

Assistant, Associate and Full Professor applications are solicited to join an enthusiastic and well-funded faculty in the Division of Microbiology and Immunology within the University of Utah’s Department of Pathology. Tenure-track faculty positions are available at all ranks. Candidates with expertise in
neuroimmunology, human immunology, host-pathogen interactions (bacterial, viral, fungal and parasitic), and mucosal immunology/ microbiome are particularly encouraged to apply. The primary criteria for selection will be excellence and creativity in research and scholarship. The ideal candidates must have a MD, PhD, or DVM degree and a research track record that supports an independent research program and complements ongoing research at the institution. The successful candidate will join a Division with active research in T cell biology, MHC structure, autoimmunity (MS, Diabetes, SLE), miRNA, microbiome,
cancer immunology, fibrosis, and infection immunology including labs focused on Borrelia, Cryptococcus, E.coli, HIV, malaria, and Schistosomiasis. Faculty rank will be commensurate with experience and appointments will include competitive start-up packages.

The University of Utah is located in Salt Lake City, a vibrant and progressive town that sits in the foothills of the Wasatch Mountain Range. This offers a truly unique mix of city life, outdoor activities and a world-class biomedical research program. The University of Utah is adjacent to ARUP national reference laboratory, a worldwide leader in innovative laboratory research and development. Interested candidates should submit electronically to https://utah.peopleadmin.com/postings/113246 a curriculum vitae, a brief cover letter, the names and addresses of three references and a 2-page
description of anticipated research directions.

More information at www.path.utah.edu/recruiting or you may contact brian.evavold@path.utah.edu. The University of Utah Health (U of U Health) is a patient focused center distinguished by collaboration, excellence, leadership, and respect. The U of U Health values candidates who are committed to fostering
and furthering the culture of compassion, collaboration, innovation, accountability, diversity, integrity, quality, and trust that is integral to our mission.

The University of Utah is an Affirmative Action/Equal Opportunity employer and does not discriminate based upon race, national origin, color, religion, sex, age, sexual orientation, gender identity/expression, status as a person with a disability, genetic information, or Protected Veteran status. Individuals from
historically underrepresented groups, such as minorities, women, qualified persons with disabilities and protected veterans are encouraged to apply. Veterans’ preference is extended to qualified applicants, upon request and consistent with University policy and Utah state law. Upon request, reasonable
accommodations in the application process will be provided to individuals with disabilities. To inquire about the University’s nondiscrimination or affirmative action policies or to request disability accommodation, please contact:

Director, Office of Equal Opportunity and Affirmative Action
201 S. Presidents Circle, Rm 135
(801) 581-8365

The University of Utah values candidates who have experience working in settings with students from diverse backgrounds, and possess a strong commitment to improving access to higher education for historically underrepresented students.
 


Postdoctoral Training Program in Developmental Biology and Regenerative Medicine - University of Colorado Anschutz Medical Campus, Aurora, Colorado

Our Mission
The Section of Developmental Biology, headed by Dr. Bruce Appel, at the University of Colorado School of Medicine, with support from the Gates Frontiers Fund, established the DevBioPostDoc Program to advance the next generation of scientific leaders in Developmental Biology and Regenerative Medicine. The DevBioPostDoc Program trains future postdoctoral fellows to become scientific experts through cutting-edge research and close guidance from principal investigators at the CU Anschutz Medical Campus.

The Position
The DevBioPostDoc Program intends to attract research-driven scientists from across the world and encourages those who want to pursue an academic scientific research to apply. Postdoc trainees are provided with a salary support in accordance with the NIH pay scale and a full benefits package from the University of Colorado. Successful applicants will be appointed as Gates Fellows with initial appointments made for one year and continued support contingent on satisfactory progress.

Our Story
Member labs of the DevBioPostDoc program use diverse model systems to address a broad range of questions in the areas of Developmental Biology, Disease Modeling, and Regenerative Medicine. Read more about the research of our principal investigators at the Section of Developmental Biology here.
Read the stories of our current DevBioPostDoc trainees here.

Application Process
Applicants must have a Ph.D. degree and less than two years of postdoctoral experience. Interested candidates submit 1) a statement explaining their motivation to join the program and indicating their preferred host lab (2-page maximum), 2) CV and 3) arrange for three references. Review of applications will begin immediately and finalists will be invited for virtual interviews. Applications should be submitted here.

For more information, we encourage you to contact Dr. Charles Sagerström, Co-Director of the Postdoctoral Training Program, charles.sagerstrom@cuanschutz.edu and Dr. Alexa Burger, Co-Director of the Postdoctoral Training Program, alexa.burger@cuanschutz.edu.

If you want to learn more about the DevBioPostDoc program and to communicate with the postdoctoral
trainees, please email them directly cudevbiopostdocs@gmail.com.
 


Open Postdoctoral Research Position - Tumor Immunology

The Department of Internal Medicine, Division of Gastroenterology is seeking a highly motivated Postdoctoral Fellow to study novel immunotherapy approaches for gastrointestinal cancers.  Experience with mouse work, flow cytometry, and immune cell assays is preferable. Applicants must have obtained a PhD in cancer biology, immunology, or a related field within the past three years.  Strong oral and written English skills are required.  The successful candidate should have independent research skills and a track record of success in the laboratory.

Interested applicants please submit a CV and contact information for 3 references to ellen.beswick@hsc.utah.edu
 


Open Postdoctoral Research Position

The Puri Lab at the University of Utah seeks to hire a postdoctoral research associate to work on a funded project studying the biosynthesis of natural products made by underexplored bacteria. The ideal candidate will have a Ph.D. in Biochemistry, Chemistry, Microbiology, or a related field, and experience with protein expression, purification, and enzymology.

Interested applicants should contact Aaron Puri directly (a.puri@utah.edu) with a cover letter, CV, and contact information for 3 references.
 


SEAL (Science Excelerator and Leadership) Program Position Ope

With this change in mind, the Gregg lab at the University of Utah is transitioning to a new model of science and discovery that caters to professional scientists by launching the SEAL (Science Excelerator and Leadership) Program. We are investigating new ways to take on higher impact scientific problems and make major advances in a shorter period of time. To help with this, the lab will transition to a new name – the Precision Brain Genetics Lab. This name change reflects the focus of the science and important roles of senior investigators in the lab and their capability to obtain independent grants if they wish. Right now, we are seeking to recruit a new SEAL program scientist to the lab at the level of a career track assistant professor, staff scientist or postdoctoral fellow.
 


Postdoctoral Research Fellow in Iron Biology at Massachusetts General Hospital and Harvard Medical School

An NIH-funded postdoctoral fellow position is available immediately in the Babitt laboratory at Massachusetts General Hospital (MGH) and Harvard Medical School to elucidate novel molecular and cellular mechanisms involved in iron homeostasis. A particular focus of the laboratory is to identify the molecular basis by which bone morphogenetic proteins regulate iron metabolism and the links between these pathways and the crippling complications of iron disorders and chronic kidney disease. We employ state-of-the-art multidisciplinary experimental approaches, including novel mouse genetic models, primary cell isolation and culture, signal transduction assays, advanced microscopy techniques, flow cytometry, and multiomic approaches, among others. Postdoctoral fellows will benefit from a highly collaborative environment and connections to premier biomedical institutions in the greater Boston area.

Candidates for this position must have a Ph.D. (or equivalent) in the biomedical sciences. Ideal applicants will have an experimental background in molecular/cellular biology and mouse models of disease, a strong publication record, and excellent communication/interpersonal skills. 

If interested, please email a cover letter, CV, and the contact information for three references to: 

Jodie L. Babitt, M.D.
Associate Professor of Medicine
Director of Translational Nephrology
Massachusetts General Hospital
Harvard Medical School
babitt.jodie@mgh.harvard.edu
 


Post-Doctoral Opportunity at University of South Carolina

A post-doctoral position is immediately available in the laboratories of Drs. John J. Lemasters and Anna-Liisa Nieminen in the Departments of Biochemistry & Molecular Biology, and Drug Discovery & Biomedical Sciences at the Medical University of South Carolina in Charleston, South Carolina. This is a joint NIH-funded research project to examine the molecular pathways of mitochondrial iron uptake and release in hepatocytes and ultimately in the liver. To address the questions posed, we will utilize a variety of hepatocyte-specific transgenic mouse strains, affinity enrichment-mass spectrometry, confocal/super-resolution/intravital multiphoton microscopy, and a newly developed mitochondrial iron sensor. Collectively, information gained from this project will impact several different pathologies where mitochondrial iron uptake plays a pathogenic role.

We are seeking a motivated and energetic scientist who can work independently, and who will be mentored in a collaborative and productive research environment addressing mitochondrial biology and cell injury. Extensive training in confocal/super-resolution/intravital imaging will be provided.

The successful candidate should have a recent PhD, MD, or equivalent. Priority will be given to qualified candidates with a strong background in molecular and cellular biology. Experience with rodent models is also preferred, but not required. Salary will follow NIH guidelines commensurate with training and experience.

If interested, please send a letter describing your research experience/interests/future career goals, CV, and contact information for three references electronically to:

John J. Lemasters, MD, PhD
jjlemasters@musc.edu

Anna-Liisa Nieminen, PhD
nieminen@musc.edu
 


Staff Scientist (Mass Spectrometry)

The Monell Chemical Senses Center is a nonprofit, basic research institute dedicated primarily to research in smell and taste.  The Center is located on the campus of the University of Pennsylvania in Philadelphia and has close ties to Penn as well as other Universities in Philadelphia.  Center research focuses on understanding how the chemical senses function and their importance in regulating behavior and physiology.

Monell seeks a staff scientist for the George Preti Research Support Core for Analytical Chemistry.  The scientist will be responsible for analysis of complex biological samples.  The successful candidate will have method development experience, including UPLC and exact mass spectrometry.  Primary responsibilities will be to provide research support to Monell scientists with an emphasis on metabolomics and lipidomics. Experience with metabolite ID and small molecule characterization is a plus.

Qualifications
-    Broad experience with mass spectrometry and method development
-    Ability to rely on experience and judgment to plan and accomplish goals and perform a variety of complicated tasks
-    Demonstrated ability to apply creativity in solving complex analytical problems
-    Ability to work in a collaborative environment
-    The ability to work with little supervision and a strong work ethic is critical
-    Exceptional verbal and written communication skills (English)
-    B.S. degree in chemistry or associated discipline and 2+ years of hands‐on LC/MS/MS experience (graduate degree preferred)
-    Experience with metabolomics and/or lipidomics applications
-    Experience with both targeted and non‐targeted assays
-    Experience with Orbitrap‐based mass spectrometers and Compound Discover and/or Acquire X software is a plus

How to Apply
Interested applicants should submit the following documents to http://apply.interfolio.com/84417
-   Cover letter describing your experience
-   Curriculum vitae including salary history
-   Contact information of three references
 


Postdoctoral Training Opportunities with the Metabolism and Nutrition Training Program (MANTP) at UW-Madison

Up to 3 years of funding of your salary at NIH postdoctoral rates in a highly collegial community of scientists focused on the molecular, genetic, biochemical and clinical and population-based aspects of nutrition-related biomedical research.

Mock-review of your F32 or similar postdoctoral fellowship proposal in study section composed of other trainees and faculty trainers.

Gain experience at grant reviewing via participation as a reviewer in MANTP mock study section.

Funds (up to $2500) to pay help pay for unique professional development opportunities such as a class at Cold Spring Harbor Laboratories.

Trainee-specific meetings (2-4 / semester) with outside speakers from academia, industry and other venues to discuss career trajectories and opportunities.

Annual meetings to discuss the research progress of all trainees including opportunities to deliver a “chalk-talk” that addresses the broad relevance of your work and its applicability to the NIH mission.

Integrative annual retreat with U Chicago T32 on “Digestive Diseases and Nutrition” where the focus is on increased exposure to cutting edge translational research, improving research presentations at national meetings, professional development activities and networking.

Opportunities to mentor young investigators.

Guidance from the MANTP Executive Committee in planning your career trajectory – both short- and long-term.

Input regarding application letters, CVs, research presentation and what to expect in interviews.

Applicants should send a cover letter describing research background and career goals, curriculum vitae and three letters of reference to:

Rick Eisenstein Ph.D.
Dept. of Nutritional Sciences, University of Wisconsin
1415 Linden Drive, Madison, WI 53706
Email contact: eisenstein@nutrisci.wisc.edu

UW-Madison is an equal opportunity/affirmative action employer.We promote excellence through diversity and encourage all qualified individuals to apply.
Positions are open only to U.S. citizens and non-citizen nationals per NIH policy.

 


Tisch Cancer Institute Postdoctoral Position open 10/23/20

A Postdoctoral position is currently available within the lab of Dr. Yelena Ginzburg at the Tisch Cancer Institute at the Icahn School of Medicine of Mount Sinai. The lab focuses on iron metabolism and erythropoiesis in health and disease, using mouse models and human samples ex vivo to ask questions about basic biology, physiology, and pathophysiology.

The candidate PhD or MD/PhD in biochemistry, physiology, or molecular biology will have an opportunity to contribute to and shape several ongoing projects within the lab.

For more information about this position and instructions on how to apply, please click here.