The CCEH program supports pilot and feasibility program grants funding small projects aimed to at generating preliminary data for inclusion in larger grant applications as well as short-term enrichment activities to learn new techniques. The grants will be awarded competitively and are designed to support collaborative research projects that utilize core resources at one of the five CCEH centers.
Current P&F Projects
|Title||PI, Key Personnel, Mentor, etc.||Investigator Institutions||Center/Core(s) to Be Used||At Center/Core Institutions|
|Resolving a controversy about the bone marrow hematopoietic niche||Konstantinos Kokkaliaris, PI; David T. Scadden, mentor||Harvard||Viral Vectors & Gene Editing Tools (Hutch); Mouse Embryonic Stem (ES) Cell and Gene Targeting Core (Boston)||Fred Hutch, Boston Children's Hospital|
|Modeling a-thalassemia using hiPSCs to investigate the role of telomere cohesion on aglobin expression||Mahesh Ramamoorthy and Merlin Nithya Gnanapragasam, MPI;||Cleveland State University||Stem Cell Core Facility||Boston Children's Hospital|
|HMGA1 Chromatin Regulators in Regenerative Capacity of Human Hematopoietic Stem Cells||Linda M. S. Resar, PI||Johns Hopkins University School of Medicine||Engineering of primary human CD34+ cells||Yale University|
|The Role of Intercellular Communication between Bone Marrow Niche Cells and Megakaryocytic-Erythroid Progenitors||Vanessa Scanlon, Pi; Beverly Torok-Storb and Diane Krause, Mentors||Yale University||Hematopoietic Cell Procurement and Processing Services||Fred Hutch|
|Evaluating Insulin-Like Growth Factor-1 (IGF1) As a Targetable Mechanism to Rescue Human Hematopoietic Stem Cell Aging||Jennifer J. Trowbridge, PI||JAX||Hematopoietic Cell Procurement and Processing Services||Fred Hutch|
|Characterization of macrophage immune-metabolic skewing induced by heme, iron and erythrophagocytosis||Francesca Vinchi, PI||NY Blood Center||Metabolomics Core||University of Utah|
|The role of the reductases Lcytb and Steap3 in lysosomal iron recycling in macrophages||Diane M Ward, PI||University of Utah School of Medicine||Metabolomics and Iron and Heme Cores||University of Utah|
|Metabolomic Investigation of Mitochondrial Heme Metabolon Proteins||Amy E. Medlock, PI||University of Georgia, Augusta University/University of Georgia Medical Partnership||Metabolomics, Iron and Heme, and MGD Cores||University of Utah|
Meet the Investigators
Get to know the investigators behind our current P&F projects. Click on an investigator's name to visit their website.