The NIDDK U54-supported Cooperative Centers of Excellence in Hematology (CCEH) have joined forces to provide novel support mechanisms for postdocs and junior faculty who want to pursue new studies in non-malignant hematology. Center Directors welcome applicants from across the U.S. and will strive to provide equal access to the cutting-edge resources and expertise available in their centers.
Type A Support: $5,000 - $20,000 worth of “core credits” to be used to provide quick and equitable access to services and expertise offered by all CCEH cores. Rolling deadlines (ends December 1), abbreviated application forms, and streamlined review all contribute to a rapid distribution of core credits. Type A is ideally suited for trainees who want to master a new expertise or acquire a new skill to enhance their competitiveness. Type A applicants must contact the directors of the cores they wish to access and negotiate how many credits are needed for the studies proposed. Specifics of the application are shown below. Approval for support is provided by CCEH Directors.
Type B Support: $75,000 total award including F&A. Type B applicants should negotiate with their home institution for as low an F&A rate as possible. Type B applications are not required to use core resources, however, Core use is encouraged. Type B applications are intended to generate new data for future NIDDK grant applications. Therefore, Type B applications that contain preliminary data are considered nonresponsive and will not be scored. Type B applications are due October 15, 2020.
Please note: Proposed research that falls outside the NIDDK/Hematology mission will be considered nonresponsive and not be scored. The following link describes the NIDDK mission.
The grants will be awarded competitively and will undergo a peer review coordinated by the NIDDK Hematology Central Coordinating Center (HCCC). Rankings will be based on significance, innovation, approach, feasibility, and the prospect of the applicant obtaining subsequent extramural funding to continue the line of research.
- For any application proposing to use CCEH Cores, applicants must contact specific Core Directors to discuss research needs and estimated costs (resources available through the CCEH Cores can be found here: http://www.cceh.io/services).
- Project periods are limited to 6 months, all funds must be spent by June 30, 2021.
- Applicants may be from any registered, domestic (U.S.), eligible organization.
- Applications for Type A projects do not require Institutional sign off by the applicant’s grant and contract office, unless required by the applicant institution’s policies.
Applications for Type A projects will be accepted on a rolling basis through December 1, 2020.
Applications for Type B projects are due by October 15, 2020.
New applications, only, should be uploaded as a single PDF file (11-point Arial font size and 0.5” margins) that must include:
- Title, PI and any Key Personnel or Sponsor, Abstract, 1 page
- Project Description, Significance, 1 page
- Figures and Literature Cited, 1 page
- Core use, Budget, and Justification, (for trainees, signed by lab PI), 1 page
- NIH-style Biosketch (only one biosketch).
New applications, only, should be uploaded as a single PDF file (11-point Arial font size and 0.5” margins).
Use the PHS 398 form (https://grants.nih.gov/grants/funding/phs398/phs398.html) including face, abstract, detailed budget, biographical and other support pages, and research plan. The research plan is limited to 5 pages and should include the following sections:
- Specific Aims
- Background and Significance
- Research Design and Methods
Pages not counted but to be included are:
- Literature Cited
- Vertebrate Animals and/or Protection of Human Subjects (if applicable)
- Sharing Plan
- Budget (costs, 8% F&A, PHS 398 fp4 and fp5), justification to ensure direct dollars to the awardee are sufficient to achieve the proposed goals
Extensive preliminary data on this project is an indication that the project is beyond the scope of this FOA.
Budgets are limited to $75,000 total costs (inclusive of all F&A costs) and will be administered as a subaward to an active NIDDK Hematology Centers grant. If in-kind services from a CCEH are proposed, the total costs for the award should be reduced by the negotiated costs of the in-kind services.
Please upload a single PDF of your application using the form in the Funding Opportunities section below.
For Type B - Applications are comparatively reviewed shortly after the due date. Only complete applications received by the due date will be reviewed.
For questions about application submission and receipt, please contact John Phillips: firstname.lastname@example.org
For scientific questions, please contact Shilpa Hattangadi: email@example.com
DIRECTIONS TO START THE APPLICATION PROCESS for Type A or Type B P & F Proposals
1. Check guidelines for eligibility.
a. Priority will be given to Junior Investigators and Postdocs.
b. Established Investigators starting a new line of Research in nonmalignant hematology - cannot be focused on currently funded project
2. Determine the type of grant you wish to apply for.
a. Type A - Core Usage Funds Only (C-UFO) up to $20,000 (no F&A, funds made available only at Core proposed).
Due on rolling basis until Dec 1, 2020.
b. Type B - New Pilot Proposal (HCCC-P&F) up to $75,000 including recommended F&A (Use PHS 398 forms as detailed).
Due Oct 15, 2020
3. Contact core director(s) of the core you will be using to initiate guidance on feasibility and costs associated with core use.
4. Write and submit proposals as a single PDF using the detailed guidelines on length and inclusions on the FUNDING link cceh.io/funding ("red" Submit box) prior to final due date and time.
No applications will be accepted after 5pm MST on the due date.
Submit Application Here
The CCEH program supports pilot and feasibility program grants funding small projects aimed at generating preliminary data for inclusion in larger grant applications. The grants will be awarded competitively and are designed to support collaborative research projects that utilize core resources at one of the five CCEH centers.
Please refer to the guidelines for writing and formatting applications (above) before submitting. Applications can be uploaded using the form to the right.
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Current P&F Projects
|Title||PI, Key Personnel, Mentor, etc.||Investigator Institutions||Center/Core(s) to Be Used||At Center/Core Institutions|
|Resolving a controversy about the bone marrow hematopoietic niche||Konstantinos Kokkaliaris, PI; David T. Scadden, mentor||Harvard||Viral Vectors & Gene Editing Tools (Hutch); Mouse Embryonic Stem (ES) Cell and Gene Targeting Core (Boston)||Fred Hutch, Boston Children's Hospital|
|Modeling a-thalassemia using hiPSCs to investigate the role of telomere cohesion on aglobin expression||Mahesh Ramamoorthy and Merlin Nithya Gnanapragasam, MPI;||Cleveland State University||Stem Cell Core Facility||Boston Children's Hospital|
|HMGA1 Chromatin Regulators in Regenerative Capacity of Human Hematopoietic Stem Cells||Linda M. S. Resar, PI||Johns Hopkins University School of Medicine||Engineering of primary human CD34+ cells||Yale University|
|The Role of Intercellular Communication between Bone Marrow Niche Cells and Megakaryocytic-Erythroid Progenitors||Vanessa Scanlon, Pi; Beverly Torok-Storb and Diane Krause, Mentors||Yale University||Hematopoietic Cell Procurement and Processing Services||Fred Hutch|
|Evaluating Insulin-Like Growth Factor-1 (IGF1) As a Targetable Mechanism to Rescue Human Hematopoietic Stem Cell Aging||Jennifer J. Trowbridge, PI||JAX||Hematopoietic Cell Procurement and Processing Services||Fred Hutch|
|Characterization of macrophage immune-metabolic skewing induced by heme, iron and erythrophagocytosis||Francesca Vinchi, PI||NY Blood Center||Metabolomics Core||University of Utah|
|The role of the reductases Lcytb and Steap3 in lysosomal iron recycling in macrophages||Diane M Ward, PI||University of Utah School of Medicine||Metabolomics and Iron and Heme Cores||University of Utah|
|Metabolomic Investigation of Mitochondrial Heme Metabolon Proteins||Amy E. Medlock, PI||University of Georgia, Augusta University/University of Georgia Medical Partnership||Metabolomics, Iron and Heme, and MGD Cores||University of Utah|
Meet the Investigators
Get to know the investigators behind our current P&F projects. Click on an investigator's name to visit their website.