About
Speakers
* = full talk selected from abstracts
Agenda
7:00 AM–8:50 AM
BREAKFAST (for guests of the 21C Hotel)
21C Hotel MAIN GALLERY (on the second floor of the hotel)
8:00 AM
Registration Desk Opens
9:00 AM
SESSION # 1 The “MEGaverse”Â
– CHAIR: Kellie Machlus
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
9:00 AM
1 Psaila
The nuclear genome of megakaryocytes and platelets – from polyploidy to DNA fragments
Beth Psaila, University of Oxford
9:20 AM
2 Hitchcock
Designing thrombopoietin modifications to uncouple its pleiotropic activities.
Ian Hitchcock, University of York England
9:40 AM
3 Machlus
Megakaryocytes present Major Histocompatibility Complex Class II antigen that directs T cell responses in the bone marrow
Kellie Machlus, Boston Children's Hospital
10:00 AM
BREAK
10:30 AM
SESSION # 2 Hematopoiesis, inflammation, and neutrophils
– CHAIR: Andres Hidalgo
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
10:30 AM
4s CarlessoÂ
LPS-mediated severe inflammation redirects bone marrow hematopoietic stem cell cycling and differentiation fate by reshaping their chromatin architecture at long-termÂ
Nadia Carlesso, Beckman Research Institute of City of Hope
10:40 AM
5s Jordan Â
Deep proteomic analysis reveals shared terminal mechanisms for Familial Hemophagocytic Lymphohistiocytosis and Lymphoma-Associated Hyperinflammation.
Michael B. Jordan, Cincinnati Children's HospitalÂ
10:50 AM
6s Barnes
STK25, a new modulator of steady-state and inflammation-induced myelopoiesis
Betsy Barnes, The Feinstein Institutes for Medical Research
11:00 AM
7s Silberstein
Neutrophil-derived Sema4A is a non-cell autonomous regulator of emergency myelopoiesis that preserves stemness of myeloid-biased HSC
Lev Silberstein, Fred Hutchinson Cancer Research Center
11:10 AM
8s LipkaÂ
Mutant Idh1 blocks neutrophil maturation by repressing myeloid progenitor programsÂ
Daniel Lipka, German Cancer Research Center (DFKZ)
11:20 AM
9 Hidalgo
Mapping neutrophilsÂ
Andres Hidalgo, Yale University
11:40 AM
10 Ng
Charting the tumor microenvironment landscape with neutrophilsÂ
Lai Guan Ng, Shanghai Immune Therapy Institute Â
12:00 PM
LUNCH “Lemonade”Â
“Marble Foyer” (in front of P&G Hall) of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
12:50 PM
LUNCH ENDS: please make your way to the auditorium
1:00 PM
SESSION # 3 – RBCÂ
– CHAIR: Lionel Blanc
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
1:00 PM
11 Blanc
Irf5 contributes to imbalanced blood production during aging through iron sensing within erythromyeloblastic islands.
Lionel Blanc, The Feinstein Institutes for Medical Research
1:20 PM
12 Kalfa
scRNAseq of more than 45,000 erythromyeloblastic island (EMBI) macrophages reveals the heterogeneity of the EMBI niche during baseline and stress erythropoiesis
Theodosia Kalfa, Cincinnati Children’s Hospital
1:40 PM
13 NarlaÂ
Mechanistic insights into anemia of Myelodysplasia
Mohandas Narla, New York Blood Center
2:00 PM
SESSION # 4Â Lymphoid and marrow niche
– CHAIR: Harinder Singh
2:00 PM
14 Ganuza
Genetic-based identification of the cellular interactome that supports T-cell development in the thymus.
Miguel Ganuza, Queen Mary University of London
2:20 PM
15 Rothenberg
Controllers of the emergence of the T-lineage program from a multipotent progenitor ground state.
Ellen Rothenberg, California Institute of TechnologyÂ
2:40 PM
16 Singh
Expanding the transcription factor motif lexicon of the genome regulatory codeÂ
Harinder Singh, University of Pittsburgh
3:00 PM
BREAK “Rice Krispie Treats”Â
POSTER SESSION 1
4:00 PM
SESSION # 5Â Mapping Hematopoiesis
– CHAIR: Vikram Paralkar
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
4:00 PM
17 Lucas
Differential regulation of fetal BM and liver hematopoiesis by yolk-sac-derived myeloid cells
Daniel Lucas, Cincinnati Children's and Medical Center
Â
4:20 PM
18s Blaser
Decoding transcription factor dependent enhancer-gene regulatory networks that define hematopoietic niche function.Â
Bradley Blaser, The Ohio State University
4:30 PM
19s Paralkar
Regulation of rRNA transcription in the hematopoietic tree
Vikram Paralkar, University of Pennsylvania
4:40 PM
20s Vu
Single-cell and high-resolution mapping of the RNA methylation landscape revealed epitranscriptomic signatures of hematopoietic stem/progenitor cell identities
Ly Vu, University of British Columbia
4:50 PM
21 Naik
Resolving the regulators of human haematopoiesis at a clonal level using cellular barcoding, SIS-seq, and a novel in vitro model of multilineage human haematopoiesisÂ
Shalin H. Naik, WEHI Australia Â
5:10 PM
22 Rodriguez-FraticelliÂ
Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespanÂ
Alejo E. Rodriguez-Fraticelli, The Barcelona Institute of Science and Technology
5:30 PM
23 DeZern
 The MDS patient-centric view of clinical and laboratory science
Sponsored by EvansMDS
Amy Dezern, Johns Hopkins
Hetty Carraway, Cleveland Clinic
Jacqueline Garcia, Dana-Farber Cancer Institute
Uma Borate, OSUCCC
6:30 PM
TRAVELÂ
WALKÂ across the street to Cincinnati Contemporary Arts CenterÂ
44 E 6th St, Cincinnati, OH 45202
6:30 PM–9:00 PM
EVENING EVENT "BLACK FLORAL"
(Lee recreates his favorite food-trend merger: black and purple food + edible floral)
7:00 AM–8:50 AM
BREAKFAST (for guests of the 21C Hotel)
21C Hotel MAIN GALLERY (on the second floor of the hotel)
9:00 AM
SESSION # 6 “From the mouth of babes”
– CHAIR: Anna Beaudin
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
9:00 AM
24 Beaudin
Metabolic programming of adult hematopoietic stem cell function by prenatal folate status
Anna Beaudin, University of Utah
9:20 AM
25 Zon
ROS and TLR signaling balance eat me and don’t eat signals to determine stem cell clonal selection by macrophages
Len Zon, Boston Children's Hospital
9:40 AM
26 Grimes
Unified single-cell methods sort divergent fates from gene regulation
Lee Grimes, Cincinnati Childrens Hospital
10:00 AM
BREAK
10:30 AM
SESSION # 7 HSC #1
– CHAIR: Marie-Dominique Filippi
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
10:30 AM
27s Tong
Lnk/Sh2b3 deficiency enhances DNA damage tolerance to promote hematopoietic stem cell fitness
Wei Tong, University of Pennsylvania
10:40 AM
28 Bigas
Genome-wide CRISPRa screen identifies genes to generate multipotent hematopoietic progenitors from mouse embryonic stem cells with engraftment capability
Anna Bigas, IMIM Barcelona Spain
11:00 AM
29 Nimer
TAF1, the largest subunit of TFIID, is dispensable for adult hematopoiesis
Stephen Nimer, University of Miami Sylvester Comprehensive Cancer Center
11:20 AM
30 Passegué
HSCs engage a cytoprotective nucleolar stress response that provides resilience during aging
Emmanuelle Passegué, Columbia University Irving Medical Center
11:40 AM
31 Filippi
A branch chain amino acid rheostat controls hematopoietic stem cell replicative lifespan
Marie-Dominque Filippi, Cincinnati Children’s Hospital
12:00 PM
LUNCH “JUHU BEACH CLUB”
“Marble Foyer” (in front of P&G Hall) of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
12:50 PM
LUNCH ENDS: please make your way to the auditorium.
1:00 PM
SESSION # 8 HSC #2
– CHAIR: Sara Meyer
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
1:00 PM
32 Figueroa
Age-related changes in BRD9 regulate human granulocytic progenitor cell fate through chromatin remodeling
Ken Figueroa, University of Miami Sylvester Comprehensive Cancer Center
1:20 PM
33 Milsom
Serial single cell transplantation experiments demonstrate a link between engraftment kinetics; HSC reconstitution; and apparent lineage biases
Michael Milsom, German Cancer Research Center (DKFZ)
1:40 PM
34 Trowbridge
Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3aR878H-driven Clonal Hematopoiesis
Jennifer Trowbridge, The Jackson Laboratory
2:00 PM
35 Goodell
Native Clonal Hematopoiesis in the mouse
Margaret Goodell, Baylor College of Medicine
2:20 PM
36s King
Epigenomic profiling of myeloid cells and progenitors identifies cell types and gene targets critical in HSPC-trained immunity
Katherine King, Baylor College of Medicine
2:30 PM
37s Buckley
Role of ubiquitin E3 ligase UBR5 in Myelodysplastic Syndromes with Trisomy 8
Shannon Buckley, University Utah of Salt Lake
2:40 PM
38s Sashida
Trisomy 8 induces chromatin conformation changes and inter-chromosomal interaction that compromise function of hematopoietic stem cells
Goro Sashida, Medical Sciences Kumamoto University
2:50 PM
39s Meyer
HDAC7 is necessary for hematopoietic stem and progenitor cell function
Sara Meyer, Thomas Jefferson University
3:00 AM
BREAK “Cincinnati Graeter's ice cream”
POSTER SESSION 2
4:00 PM
SESSION # 9 Stress and Marrow Failure
– CHAIR: Dan Starczynowski
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
4:00 PM
40 Xie
CD83 is a functional acute inflammatory stress marker of human hematopoietic stem cells
Stephanie Xie, Princess Margaret Cancer Center
4:20 PM
41 Purton
Endothelial cell-specific loss of retinoic acid receptor gamma activity has sex-dependent effects on hematopoiesis and predisposes female mice to acquired bone marrow failure
Louise Purton, University of Melbourne
4:40 PM
42 Landau
Genotype-phenotype mapping via single-cell multi-omics identifies therapeutic vulnerabilities in VEXAS Syndrome
Dan Landau, Weill Cornell Medicine
5:00 PM
43s Starczynowski
UBA6 inhibition selectively targets mutant-UBA1 cells in VEXAS syndrome
Dan Starczynowski, Cincinnati Children’s Hospital
5:10 PM
44s Bryder
Hematopoietic rejuvenation and leukemia prevention in aged recipients: Efficacy of low-intensity conditioning and prophylactic transplantationÂ
David Bryder, Lund Stem Cell Center
5:20 PM
45 Batista
Identification and regulation of novel pathways mediating decay of the telomerase RNA component to restore hematopoietic development in bone marrow failure mutants
Luis Batista, Washington University in St. Louis
5:40 PM
46 Lindsley
Using TERT variant-to-function analysis to define the contribution of cryptic telomerase dysfunction to hematologic phenotypes in the population
Coleman Lindsley, Dana-Farber Cancer Institute
6:00 PM
TRAVEL OPTIONS
SHUTTLES
WALK 16 min/0.7 mile
STREETCAR Cincinnati Bell connector is free
DESTINATION: Memorial Hall
1225 Elm St, Cincinnati, OH 45202Â
6:30 PM–9:00 PM
EVENING EVENT “BOO to YOU”Â
(…if Disney’s Haunted Mansion had a restaurant in a Beaux-Arts theater built just before the death of Edward VII and the sinking of the Titanic)
7:00 AM – 8:50 AM
BREAKFAST (for guests of the 21C Hotel)
21C Hotel MAIN GALLERY (on the second floor of the hotel)
9:00 AM
SESSION # 10 Factors underlying AML outcomes
– CHAIR: Iannis AifantisÂ
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
9:00 AM
47 Eisfeld
Genomic profiles and associated survival prognosticators in ancestry-diverse patients with AML: Refining the genetic landscape and new biologic insights
AK Eisfeld, The Ohio State University
9:20 AM
48 Loghavi
Characterization and relevance of immunophenotypic changes following Menin inhibition in AML
Sanam Loghavi, MD Anderson Cancer Center
9:40 AM
49 Aifantis
Transcriptional and post-translational regulation of cytotoxic T-cell responses in AML
Iannis Aifantis, NYU Grossman School of Medicine
10:00 AM
BREAK
10:30 AM
SESSION # 11 Selection
– CHAIR: Stephanie Halene
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
10:30 AM
50s Pear
Trib1 regulates neutrophil differentiation, lifespan, and functionÂ
Warren Pear, University of Pennsylvania
10:40 AM
51 Crispino
Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A
John Crispino, St. Jude Children’s Research Hospital
11:00 AM
52 Halene + Krause
The RBM15-MKL1 fusion protein mediated m6A RNA modification promotes leukemia by regulating expression of Fzd genes
Stephanie Halene + Diane Krause, Yale University School of Medicine
11:20 AM
53s Lee
IGF2BP1 is essential for ETO2/GLIS2 leukemogenesis via stabilization of primitive hematopoietic transcriptional programs
Lynn Lee, Cincinnati Children's Hospital
11:30 AM
54s Tenen
Genome-wide Methylation Sensitive Elements (MESAs) are targetable regulatory elements for controllable gene activation
Daniel G. Tenen, Cancer Science Institute of Singapore
11:40 AM
55s Bowman
Early drivers of clonal hematopoiesis shape the subsequent evolutionary trajectories of de novo AML
Robert Bowman, University of Pennsylvania
10:40 AM
56s Miles
Clonal selection and evolution in Acute Myeloid Leukemia
Linde Miles, Cincinnati Children’s Hospital
12:00 PM
LUNCH “Brad’s-Birthday” (This is not Brad’s birthday)Â
“Marble Foyer” (in front of P&G Hall) of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
12:50 PM
LUNCH ENDS: please make your way to the auditorium
1:00 PM
SESSION # 12 Progression
– CHAIR: Ross Levine
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
1:00 PM
57 Majeti
DNMT3A:R882H is not required for disease maintenance in AML, but is associated with increased leukemia stem cell frequency
Ravindra Majeti, Stanford University
1:20 PM
58 LevineÂ
CRISPR dependency studies primary hematopoietic stem cells identify genotype specific vulnerabilities in IDH2- and TET2- Mutant Cells
Ross Levine, Memorial Sloan Kettering Cancer Center
1:40 PM
59 Vyas
Transcription factor deregulation in pre-leukaemia of Down Syndrome
Paresh Vyas, Weatherall Institute of Molecular Medicine
2:00 PM
60 Walter
Primary U2AF1S34F mutated hematopoietic cells are sensitive to nonsense-mediated RNA decay disruption in vivo
Matthew J. Walter, Washington University School of Medicine
2:20 PM
61s Hertlein
Comparison of Npm1cA; Ptpn11E76K and Npm1cA; Flt3ITD – two fully immunocompetent in vivo models of AML
Erin Hertlein, University of Cincinnati College of Medicine
2:30 PM
62s Muntean
SETDB1 mediated gene regulation contributes to methionine demand in leukemia
Andrew Muntean, University of Michigan Medical School
2:40 PM
63s GoyamaÂ
SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance specifically in Monocytic AML
Susumu Goyama, University of Tokyo
2:50 PM
64s Wagenblast
Quiescent stem-like signature in NUP98-NSD1 fusion-driven leukemia reveals vulnerabilities in oxidative phosphorylation
Elvin Wagenblast, Icahn School of Medicine
3:00 PM
BREAK “cupcakes to make Dr. Figueroa happy”
POSTER SESSION 3
4:00 PM
SESSION # 13 Models and Targets
– CHAIR: Aaron Viny
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
4:00 PM
65s Viny
Cohesin mutations prevent HSC chromatin silencing of Fli1 targets to exit stemness
Aaron D. Viny, Columbia University Irving Medical Center
4:10 PM
66s Maxson
Biallelic Cebpa mutations alter chromatin accessibility and STAT activity
Julia Maxson, Oregon Health & Science University Â
4:20 PM
67 Pulikkan
C/EBPα-p30 deregulates SWI/SNF complex in CEBPA mutant AML
John A. Pulikkan, Versiti Blood Research Institute
4:40 PM
68s Chai
Targeting transcription factors through an IMiD independent zinc finger domainÂ
Li Chai, Harvard Medical School
4:50 PM
69s Bhatia
The arginine methyltransferase PRMT5 regulates maintenance and TKI resistance of self-renewing FLT3-ITD AML LSC
Ravi Bhatia, University of Alabama at Birmingham
5:00 PM
70s Grieselhuber
TAIRE kinase inhibition downregulates canonical Wnt/β-catenin signaling in AMLÂ
Nicole R. Grieselhuber, The Ohio State University
5:10 PM
71s Volk
Lineage plasticity in response to therapy is a targetable mechanism of resistance in AML
Andrew Volk, Cincinnati Children's Hospital
5:20 PM
72s Milyavsky
Drug persistence to resistance evolution analysis in human leukemia reveals diverse leukemia-initiating cell phenotypes
Michael Milyavsky, Tel Aviv University
5:30 PM
73 Steidl
Understanding and targeting stem cell transcription dynamics
Ulrich Steidl, Albert Einstein College of Medicine
6:00 PM
TRAVEL OPTIONS
SHUTTLES
WALK 12 min/0.6 mile
STREETCAR Cincinnati Bell connector is free
DESTINATION:Â Anderson Pavilion Â
8 E Mehring Way, Cincinnati, OH 45202
6:30 PM – 9:30 PM
EVENING EVENT “Cicchetti-Go-Round “
Venice Wine-bar small-bite culture and a fully functional giant in door Carousel…what could possibly go wrong?
7:00 AM – 8:50 AM
BREAKFAST (for guests of the 21C Hotel)
21C Hotel MAIN GALLERY (on the second floor of the hotel)
9:00 AM
SESSION # 14 Deregulating Hematopoiesis
– CHAIR: Rob Welner
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
9:00 AM
74 Ghisletti
Activation of distinct genomic regions identify subsets of MDS patients characterized by immune response activation
Serena Ghisletti, UniversitĂ degli Studi di Milano "
9:20 AM
75 Huang
Downregulation of Mitochondrial Complex II in Myelodysplastic Syndromes
Gang Huang, UT Health San Antonio
9:40 AM
76 Welner
Combined single-cell signaling with transcriptomic profiling reveals insight into the selection of hematopoietic stem cells in Clonal Hematopoiesis
Robert S Welner, University of Alabama O'Neal Comprehensive Cancer Center
10:00 AM
BREAK
10:30 AM
SESSION # 15 Leukemia Stem Cells
– CHAIR: Eirini Papapetrou
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)
10:30 AM
77s Tikhonova
IRF5 defines a new high-risk inflammatory T-lineage acute lymphoblastic leukemia subtype
Anastasia N. Tikhonova, University of Toronto Princess Margaret Cancer Cente
10:40 AM
78 Jones
Targeting polyamine metabolism in acute myeloid leukemia stem cells
Courtney Jones, Cincinnati Children’s Hospital
11:00 AM
79 Dick
Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties
John Dick, University of Toronto Princess Margaret Cancer Center
11:20 AM
80 Jordan
Targeting mitochondrial calcium uptake to eradicate Venetoclax-resistant Acute Myeloid Leukemia Stem Cells
Craig Jordan, University of Colorado, Denver
11:40 AM
81 Papapetrou
Separating and uniting genetic and non-genetic hierarchies in human AML
Eirini Papapetrou, Mount Sinai
12:00 PM
LUNCH “ Lunch for traveling”Â
BOX LUNCH TAKEAWAY
1:00 PM
BUS 1 will transport directly to CVG
1:30 PM
BUS 2 will transport directly to CVG