Cincinnati CCEH sponsored biennial Myeloid Workshop May 2024

7:00 AM–8:50 AM

BREAKFAST (for guests of the 21C Hotel)
21C Hotel MAIN GALLERY (on the second floor of the hotel)

8:00 AM

Registration Desk Opens

9:00 AM

SESSION # 1 The “MEGaverse” 
– CHAIR: Kellie Machlus
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

9:00 AM

1 Psaila

The nuclear genome of megakaryocytes and platelets – from polyploidy to DNA fragments
Beth Psaila, University of Oxford

9:20 AM

2 Hitchcock
Designing thrombopoietin modifications to uncouple its pleiotropic activities.
Ian Hitchcock, University of York England

9:40 AM

3 Machlus
Megakaryocytes present Major Histocompatibility Complex Class II antigen that directs T cell responses in the bone marrow
Kellie Machlus, Boston Children's Hospital

10:00 AM

BREAK

10:30 AM

SESSION # 2 Hematopoiesis, inflammation, and neutrophils
– CHAIR: Andres Hidalgo
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

10:30 AM

4s Carlesso 
LPS-mediated severe inflammation redirects bone marrow hematopoietic stem cell cycling and differentiation fate by reshaping their chromatin architecture at long-term 
Nadia Carlesso, Beckman Research Institute of City of Hope

10:40 AM

5s Jordan  
Deep proteomic analysis reveals shared terminal mechanisms for Familial Hemophagocytic Lymphohistiocytosis and Lymphoma-Associated Hyperinflammation.
Michael B. Jordan, Cincinnati Children's Hospital 

10:50 AM

6s Barnes
STK25, a new modulator of steady-state and inflammation-induced myelopoiesis
Betsy Barnes, The Feinstein Institutes for Medical Research

11:00 AM

7s Silberstein
Neutrophil-derived Sema4A is a non-cell autonomous regulator of emergency myelopoiesis that preserves stemness of myeloid-biased HSC
Lev Silberstein, Fred Hutchinson Cancer Research Center

11:10 AM

8s Lipka 
Mutant Idh1 blocks neutrophil maturation by repressing myeloid progenitor programs 
Daniel Lipka, German Cancer Research Center (DFKZ)

11:20 AM

9 Hidalgo
Mapping neutrophils 
Andres Hidalgo, Yale University

11:40 AM

10 Ng
Charting the tumor microenvironment landscape with neutrophils 
Lai Guan Ng, Shanghai Immune Therapy Institute  

12:00 PM

LUNCH “Lemonade” 

“Marble Foyer” (in front of P&G Hall) of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

12:50 PM

LUNCH ENDS: please make your way to the auditorium

1:00 PM

SESSION # 3 – RBC 
– CHAIR: Lionel Blanc
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

1:00 PM

11 Blanc
Irf5 contributes to imbalanced blood production during aging through iron sensing within erythromyeloblastic islands.
Lionel Blanc, The Feinstein Institutes for Medical Research

1:20 PM

12 Kalfa
scRNAseq of more than 45,000 erythromyeloblastic island (EMBI) macrophages reveals the heterogeneity of the EMBI niche during baseline and stress erythropoiesis
Theodosia Kalfa, Cincinnati Children’s Hospital

1:40 PM

13 Narla 
Mechanistic insights into anemia of Myelodysplasia
Mohandas Narla, New York Blood Center

2:00 PM

SESSION # 4  Lymphoid and marrow niche
– CHAIR: Harinder Singh

2:00 PM

14 Ganuza
Genetic-based identification of the cellular interactome that supports T-cell development in the thymus.
Miguel Ganuza, Queen Mary University of London

2:20 PM

15 Rothenberg
Controllers of the emergence of the T-lineage program from a multipotent progenitor ground state.
Ellen Rothenberg, California Institute of Technology 

2:40 PM

16 Singh
Expanding the transcription factor motif lexicon of the genome regulatory code 
Harinder Singh, University of Pittsburgh

3:00 PM

BREAK  “Rice Krispie Treats” 
POSTER SESSION 1

4:00 PM

SESSION # 5  Mapping Hematopoiesis
– CHAIR: Vikram Paralkar
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

4:00 PM

17 Lucas
Differential regulation of fetal BM and liver hematopoiesis by yolk-sac-derived myeloid cells
Daniel Lucas, Cincinnati Children's and Medical Center

4:20 PM

18s Blaser
Decoding transcription factor dependent enhancer-gene regulatory networks that define hematopoietic niche function. 
Bradley Blaser, The Ohio State University

4:30 PM

19s Paralkar
Regulation of rRNA transcription in the hematopoietic tree
Vikram Paralkar, University of Pennsylvania

4:40 PM

20s Vu
Single-cell and high-resolution mapping of the RNA methylation landscape revealed epitranscriptomic signatures of hematopoietic stem/progenitor cell identities
Ly Vu, University of British Columbia

4:50 PM

21 Naik
Resolving the regulators of human haematopoiesis at a clonal level using cellular barcoding, SIS-seq, and a novel in vitro model of multilineage human haematopoiesis 
Shalin H. Naik, WEHI Australia  

5:10 PM

22 Rodriguez-Fraticelli 
Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan 
Alejo E. Rodriguez-Fraticelli, The Barcelona Institute of Science and Technology

5:30 PM

23 DeZern
 The MDS patient-centric view of clinical and laboratory science
Sponsored by EvansMDS
Amy Dezern, Johns Hopkins
Hetty Carraway, Cleveland Clinic
Jacqueline Garcia, Dana-Farber Cancer Institute
Uma Borate, OSUCCC

6:30 PM

TRAVEL 
WALK across the street to Cincinnati Contemporary Arts Center 
44 E 6th St, Cincinnati, OH 45202

6:30 PM–9:00 PM

EVENING EVENT "BLACK FLORAL"
(Lee recreates his favorite food-trend merger: black and purple food + edible floral)

7:00 AM–8:50 AM

BREAKFAST (for guests of the 21C Hotel)
21C Hotel MAIN GALLERY (on the second floor of the hotel)

9:00 AM

SESSION # 6 “From the mouth of babes”
– CHAIR: Anna Beaudin
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

9:00 AM

24 Beaudin
Metabolic programming of adult hematopoietic stem cell function by prenatal folate status
Anna Beaudin, University of Utah

9:20 AM

25 Zon
ROS and TLR signaling balance eat me and don’t eat signals to determine stem cell clonal selection by macrophages
Len Zon, Boston Children's Hospital

9:40 AM

26 Grimes
Unified single-cell methods sort divergent fates from gene regulation
Lee Grimes, Cincinnati Childrens Hospital

10:00 AM

BREAK

10:30 AM

SESSION # 7 HSC #1
– CHAIR: Marie-Dominique Filippi
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

10:30 AM

27s Tong
Lnk/Sh2b3 deficiency enhances DNA damage tolerance to promote hematopoietic stem cell fitness
Wei Tong, University of Pennsylvania

10:40 AM

28 Bigas
Genome-wide CRISPRa screen identifies genes to generate multipotent hematopoietic progenitors from mouse embryonic stem cells with engraftment capability
Anna Bigas, IMIM Barcelona Spain

11:00 AM

29 Nimer
TAF1, the largest subunit of TFIID, is dispensable for adult hematopoiesis
Stephen Nimer, University of Miami Sylvester Comprehensive Cancer Center

11:20 AM

30 Passegué
HSCs engage a cytoprotective nucleolar stress response that provides resilience during aging
Emmanuelle Passegué, Columbia University Irving Medical Center

11:40 AM

31 Filippi
A branch chain amino acid rheostat controls hematopoietic stem cell replicative lifespan
Marie-Dominque Filippi, Cincinnati Children’s Hospital

12:00 PM

LUNCH “JUHU BEACH CLUB”
“Marble Foyer” (in front of P&G Hall) of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

12:50 PM

LUNCH ENDS: please make your way to the auditorium.

1:00 PM

SESSION # 8 HSC #2
– CHAIR: Sara Meyer
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

1:00 PM

32 Figueroa
Age-related changes in BRD9 regulate human granulocytic progenitor cell fate through chromatin remodeling
Ken Figueroa, University of Miami Sylvester Comprehensive Cancer Center

1:20 PM

33 Milsom
Serial single cell transplantation experiments demonstrate a link between engraftment kinetics; HSC reconstitution; and apparent lineage biases
Michael Milsom, German Cancer Research Center (DKFZ)

1:40 PM

34 Trowbridge
Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3aR878H-driven Clonal Hematopoiesis
Jennifer Trowbridge, The Jackson Laboratory

2:00 PM

35 Goodell
Native Clonal Hematopoiesis in the mouse
Margaret Goodell, Baylor College of Medicine

2:20 PM

36s King
Epigenomic profiling of myeloid cells and progenitors identifies cell types and gene targets critical in HSPC-trained immunity
Katherine King, Baylor College of Medicine

2:30 PM

37s Buckley
Role of ubiquitin E3 ligase UBR5 in Myelodysplastic Syndromes with Trisomy 8
Shannon Buckley, University Utah of Salt Lake

2:40 PM

38s Sashida
Trisomy 8 induces chromatin conformation changes and inter-chromosomal interaction that compromise function of hematopoietic stem cells
Goro Sashida, Medical Sciences Kumamoto University

2:50 PM

39s Meyer
HDAC7 is necessary for hematopoietic stem and progenitor cell function
Sara Meyer, Thomas Jefferson University

3:00 AM

BREAK  “Cincinnati Graeter's ice cream”
POSTER SESSION 2

4:00 PM

SESSION # 9 Stress and Marrow Failure
– CHAIR: Dan Starczynowski
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

4:00 PM

40 Xie
CD83 is a functional acute inflammatory stress marker of human hematopoietic stem cells
Stephanie Xie, Princess Margaret Cancer Center

4:20 PM

41 Purton
Endothelial cell-specific loss of retinoic acid receptor gamma activity has sex-dependent effects on hematopoiesis and predisposes female mice to acquired bone marrow failure
Louise Purton, University of Melbourne

4:40 PM

42 Landau
Genotype-phenotype mapping via single-cell multi-omics identifies therapeutic vulnerabilities in VEXAS Syndrome
Dan Landau, Weill Cornell Medicine

5:00 PM

43s Starczynowski
UBA6 inhibition selectively targets mutant-UBA1 cells in VEXAS syndrome
Dan Starczynowski, Cincinnati Children’s Hospital

5:10 PM

44s Bryder
Hematopoietic rejuvenation and leukemia prevention in aged recipients: Efficacy of low-intensity conditioning and prophylactic transplantation 
David Bryder, Lund Stem Cell Center

5:20 PM

45 Batista
Identification and regulation of novel pathways mediating decay of the telomerase RNA component to restore hematopoietic development in bone marrow failure mutants
Luis Batista, Washington University in St. Louis

5:40 PM

46 Lindsley
Using TERT variant-to-function analysis to define the contribution of cryptic telomerase dysfunction to hematologic phenotypes in the population
Coleman Lindsley, Dana-Farber Cancer Institute

6:00 PM

TRAVEL OPTIONS

1. SHUTTLES

2. WALK 16 min/0.7 mile

3. STREETCAR Cincinnati Bell connector is free

DESTINATION: Memorial Hall
1225 Elm St, Cincinnati, OH 45202 

6:30 PM–9:00 PM

EVENING EVENT “BOO to YOU” 
(…if Disney’s Haunted Mansion had a restaurant in a Beaux-Arts theater built just before the death of Edward VII and the sinking of the Titanic)

7:00 AM – 8:50 AM

BREAKFAST (for guests of the 21C Hotel)
21C Hotel MAIN GALLERY (on the second floor of the hotel)

9:00 AM

SESSION # 10 Factors underlying AML outcomes
– CHAIR: Iannis Aifantis 
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

9:00 AM

47 Eisfeld
Genomic profiles and associated survival prognosticators in ancestry-diverse patients with AML: Refining the genetic landscape and new biologic insights
AK Eisfeld, The Ohio State University

9:20 AM

48 Loghavi
Characterization and relevance of immunophenotypic changes following Menin inhibition in AML
Sanam Loghavi, MD Anderson Cancer Center

9:40 AM

49 Aifantis
Transcriptional and post-translational regulation of cytotoxic T-cell responses in AML
Iannis Aifantis, NYU Grossman School of Medicine

10:00 AM

BREAK

10:30 AM

SESSION # 11 Selection
– CHAIR: Stephanie Halene
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

10:30 AM

50s Pear
Trib1 regulates neutrophil differentiation, lifespan, and function 
Warren Pear, University of Pennsylvania

10:40 AM

51 Crispino
Chromothripsis orchestrates leukemic transformation in blast phase MPN through targetable amplification of DYRK1A
John Crispino, St. Jude Children’s Research Hospital

11:00 AM

52 Halene + Krause
The RBM15-MKL1 fusion protein mediated m6A RNA modification promotes leukemia by regulating expression of Fzd genes
Stephanie Halene + Diane Krause, Yale University School of Medicine

11:20 AM

53s Lee
IGF2BP1 is essential for ETO2/GLIS2 leukemogenesis via stabilization of primitive hematopoietic transcriptional programs
Lynn Lee, Cincinnati Children's Hospital

11:30 AM

54s Tenen
Genome-wide Methylation Sensitive Elements (MESAs) are targetable regulatory elements for controllable gene activation
Daniel G.  Tenen, Cancer Science Institute of Singapore

11:40 AM

55s Bowman
Early drivers of clonal hematopoiesis shape the subsequent evolutionary trajectories of de novo AML
Robert Bowman, University of Pennsylvania

10:40 AM

56s Miles
Clonal selection and evolution in Acute Myeloid Leukemia
Linde Miles, Cincinnati Children’s Hospital

12:00 PM

LUNCH “Brad’s-Birthday” (This is not Brad’s birthday) 

“Marble Foyer” (in front of P&G Hall) of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

12:50 PM

LUNCH ENDS: please make your way to the auditorium

1:00 PM

SESSION # 12 Progression
– CHAIR: Ross Levine
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

1:00 PM

57 Majeti
DNMT3A:R882H is not required for disease maintenance in AML, but is associated with increased leukemia stem cell frequency
Ravindra Majeti, Stanford University

1:20 PM

58 Levine 
CRISPR dependency studies primary hematopoietic stem cells identify genotype specific vulnerabilities in IDH2- and TET2- Mutant Cells
Ross Levine, Memorial Sloan Kettering Cancer Center

1:40 PM

59 Vyas
Transcription factor deregulation in pre-leukaemia of Down Syndrome
Paresh Vyas, Weatherall Institute of Molecular Medicine

2:00 PM

60 Walter
Primary U2AF1S34F mutated hematopoietic cells are sensitive to nonsense-mediated RNA decay disruption in vivo
Matthew J. Walter, Washington University School of Medicine

2:20 PM

61s Hertlein
Comparison of Npm1cA; Ptpn11E76K and Npm1cA; Flt3ITD – two fully immunocompetent in vivo models of AML
Erin Hertlein, University of Cincinnati College of Medicine

2:30 PM

62s Muntean
SETDB1 mediated gene regulation contributes to methionine demand in leukemia
Andrew Muntean, University of Michigan Medical School

2:40 PM

63s Goyama 
SETDB1 suppresses interferon responses and NK cell-mediated immunosurveillance specifically in Monocytic AML
Susumu Goyama, University of Tokyo

2:50 PM

64s Wagenblast
Quiescent stem-like signature in NUP98-NSD1 fusion-driven leukemia reveals vulnerabilities in oxidative phosphorylation
Elvin Wagenblast, Icahn School of Medicine

3:00 PM

BREAK  “cupcakes to make Dr. Figueroa happy”
POSTER SESSION 3

4:00 PM

SESSION # 13 Models and Targets
– CHAIR: Aaron Viny
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

4:00 PM

65s Viny
Cohesin mutations prevent HSC chromatin silencing of Fli1 targets to exit stemness
Aaron D. Viny, Columbia University Irving Medical Center

4:10 PM

66s Maxson
Biallelic Cebpa mutations alter chromatin accessibility and STAT activity
Julia Maxson, Oregon Health & Science University  

4:20 PM

67 Pulikkan
C/EBPα-p30 deregulates SWI/SNF complex in CEBPA mutant AML
John A. Pulikkan, Versiti Blood Research Institute

4:40 PM

68s Chai
Targeting transcription factors through an IMiD independent zinc finger domain 
Li Chai, Harvard Medical School

4:50 PM

69s Bhatia
The arginine methyltransferase PRMT5 regulates maintenance and TKI resistance of self-renewing FLT3-ITD AML LSC
Ravi Bhatia, University of Alabama at Birmingham

5:00 PM

70s Grieselhuber
TAIRE kinase inhibition downregulates canonical Wnt/β-catenin signaling in AML 
Nicole R. Grieselhuber, The Ohio State University

5:10 PM

71s Volk
Lineage plasticity in response to therapy is a targetable mechanism of resistance in AML
Andrew Volk, Cincinnati Children's Hospital

5:20 PM

72s Milyavsky
Drug persistence to resistance evolution analysis in human leukemia reveals diverse leukemia-initiating cell phenotypes
Michael Milyavsky, Tel Aviv University

5:30 PM

73 Steidl
Understanding and targeting stem cell transcription dynamics
Ulrich Steidl, Albert Einstein College of Medicine

6:00 PM

TRAVEL OPTIONS

1. SHUTTLES

2. WALK 12 min/0.6 mile

3. STREETCAR Cincinnati Bell connector is free

DESTINATION: Anderson Pavilion  

8 E Mehring Way, Cincinnati, OH 45202

6:30 PM – 9:30 PM

EVENING EVENT  “Cicchetti-Go-Round “
Venice Wine-bar small-bite culture and a fully functional giant in door Carousel…what could possibly go wrong?

7:00 AM – 8:50 AM

BREAKFAST (for guests of the 21C Hotel)
21C Hotel MAIN GALLERY (on the second floor of the hotel)

9:00 AM

SESSION # 14 Deregulating Hematopoiesis
– CHAIR: Rob Welner
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

9:00 AM

74 Ghisletti
Activation of distinct genomic regions identify subsets of MDS patients characterized by immune response activation
Serena Ghisletti, Università degli Studi di Milano "

9:20 AM

75 Huang
Downregulation of Mitochondrial Complex II in Myelodysplastic Syndromes
Gang Huang, UT Health San Antonio

9:40 AM

76 Welner
Combined single-cell signaling with transcriptomic profiling reveals insight into the selection of hematopoietic stem cells in Clonal Hematopoiesis
Robert S Welner, University of Alabama O'Neal Comprehensive Cancer Center

10:00 AM

BREAK

10:30 AM

SESSION # 15 Leukemia Stem Cells
– CHAIR: Eirini Papapetrou
Jarson-Kaplan Theater of the Aronoff Center for the Arts
650 Walnut St, Cincinnati, OH 45202
(directly across the street from the 21C Hotel)

10:30 AM

77s Tikhonova
IRF5 defines a new high-risk inflammatory T-lineage acute lymphoblastic leukemia subtype
Anastasia N. Tikhonova, University of Toronto Princess Margaret Cancer Cente

10:40 AM

78 Jones
Targeting polyamine metabolism in acute myeloid leukemia stem cells
Courtney Jones, Cincinnati Children’s Hospital

11:00 AM

79 Dick
Identification of leukemia stem cell subsets with distinct transcriptional, epigenetic and functional properties
John Dick, University of Toronto Princess Margaret Cancer Center

11:20 AM

80 Jordan
Targeting mitochondrial calcium uptake to eradicate Venetoclax-resistant Acute Myeloid Leukemia Stem Cells
Craig Jordan, University of Colorado, Denver

11:40 AM

81 Papapetrou
Separating and uniting genetic and non-genetic hierarchies in human AML
Eirini Papapetrou, Mount Sinai

12:00 PM

LUNCH “ Lunch for traveling” 
BOX LUNCH TAKEAWAY

1:00 PM

BUS 1 will transport directly to CVG

1:30 PM

BUS 2 will transport directly to CVG