Featured Publications

Suppression of Rho-associated kinase 1 (ROCK1) promotes human hematopoietic stem cell expansion by attenuating mitochondrial fission

A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice

Dysregulation in a Patient-Tailored Mouse Model of Barth Syndrome.

Enhanced Hematopoietic Stem Cell Self-Renewal and Engraftment Through Human Lung Exosomal Communication

Protection of CD33-modified hematopoietic stem cell progeny from CD33-directed CAR T cells in rhesus macaques

Multiplex base editing to protect from CD33 directed drugs for immune and gene therapy

Direct delivery of Cas-embedded cytosine base editors as ribonucleoprotein complexes for efficient and accurate editing of clinically relevant targets

Regulated GATA1 expression as a universal gene therapy for Diamond-Blackfan anemia

Multiplex imaging of murine bone marrow using Phenocycler 2.0™

Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin

The hepcidin-ferroportin axis modulates liver endothelial cell BMP expression to influence iron homeostasis in mice

Osteomacs promote maintenance of murine hematopoiesis through megakaryocyte-induced upregulation of Embigin and CD166.

CCR2 cooperativity promotes hematopoietic stem cell homing to the bone marrow.

Protocol for enrichment and functional analysis of human hematopoietic cells from umbilical cord blood

Glucose intolerance as a consequence of hematopoietic stem cell dysfunction in offspring of obese mice

Noncanonical role of ALAS1 as a heme-independent inhibitor of small RNA-mediated silencing

Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis

Identification of a divalent metal transporter required for cellular iron metabolism in malaria parasites

Biogenesis of Cytochromes c and c1 in the Electron Transport Chain of Malaria Parasites

CDK9 phosphorylates RUNX1 to promote megakaryocytic fate in megakaryocytic-erythroid progenitors

Prenatal inflammation remodels lung immunity and function by programming ILC2 hyperactivation

Low-iron-diet-induced fatty liver development is microbiota dependent and exacerbated by loss of the mitochondrial iron importer mitoferrin2

Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice

Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

Ubiquitin E3 Ligase FBXO9 Regulates Pluripotency by Targeting DPPA5 for Ubiquitylation and Degradation

Resilient anatomy and local plasticity of naive and stress haematopoiesis

Cell surface RNAs control neutrophil recruitment

Insights into highly engraftable hematopoietic cells from 27-year cryopreserved umbilical cord blood

The iron chaperone poly C binding protein 1 regulates iron efflux through intestinal ferroportin in mice

BMP5 contributes to hepcidin regulation and systemic iron homeostasis in mice

Exploiting Differences in Heme Biosynthesis between Bacterial Species to Screen for Novel Antimicrobials

The transcriptomic landscape of normal and ineffective erythropoiesis at single cell resolution

Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia

Haematopoietic stem and progenitor cell heterogeneity is inherited from the embryonic endothelium

Assay Optimization for the Objective Quantification of Human Multilineage Colony Forming Units

Gene knock-outs in human CD34+ hematopoietic stem and progenitor cells and in the human immune system of mice

Increased blood reactive oxygen species and hepcidin in obstructive sleep apnea precludes expected erythrocytosis

Macrophage metabolic rewiring improves heme-suppressed efferocytosis and tissue damage in sickle cell disease

Obesity-induced inflammation exacerbates clonal hematopoiesis

Loss of the mitochondrial protein Abcb10 results in altered arginine metabolism in MEL and K562 cells and nutrient stress signaling through ATF4

Direct tests of cytochrome c and c1 functions in the electron transport chain of malaria parasites

MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model of hyperactive GNAQ

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity

Retinoid X receptor promotes hematopoietic stem cell fitness and quiescence and preserves hematopoietic homeostasis

PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin

Functional role of endothelial transferrin receptor 1 in iron sensing and homeostasis

Genotyping of canine MHC gene DLA-88 by next-generation sequencing reveals high frequencies of new allele discovery and gene duplication

HRG-9 homologues regulate haem trafficking from haem-enriched compartments

Erythroblastic islands foster granulopoiesis in parallel to terminal erythropoiesis

Physioxia-induced downregulation of Tet2 in hematopoietic stem cells contributes to enhanced self-renewal

Identification and characterization of RBM12 as a novel regulator of fetal hemoglobin expression

Autism-associated chromatin remodeler CHD8 regulates erythroblast cytokinesis and fine-tunes the balance of Rho GTPase signaling

Nuclear translocation of TFE3 under hypoxia enhances the engraftment of human hematopoietic stem cells

Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)

Lysosomal iron recycling in mouse macrophages is dependent upon both LcytB and Steap3 reductases

Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies

Chromatin remodeling subunit BRM and valine regulate hematopoietic stem/progenitor cell function and self-renewal via intrinsic and extrinsic effects

Attenuation of apoptotic cell detection triggers thymic regeneration after damage

The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder

Is the erythropoietin-erythroferrone-hepcidin axis intact in human neonates?

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain

Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis

Highly efficient therapeutic gene editing of human hematopoietic stem cells