High titer AV, AAV, lenti, retro, and foamy virus vectors siRNA, shRNA, CRISPR/Cas9, ORFeome editing tools
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Molecular assays for tracking genetic signatures
Provide a more translational model for pre-clinical research than the mouse
Breeding NSG, NRG, and NOD/SCID mice. Generating humanized mice, imaging mice, and providing technical and mouse handling services
Hematopoietic cell processing Healthy donor apheresis G-CSF mobilized CD34+ cells
Analyzes biological samples for metal, porphyrin, heme content, heme biosynthetic enzyme activity and metals such as iron by ICP-MS
Designs and produces custom TALEN and CRISPR-Cas9 DNA nucleases for targeted genomic mutations in standard and non-standard model organisms
LC-MS & GC-MS metabolic profiling and isotope tracer analysis
We support investigators in the field of non-malignant hematology through workshops, pilot and feasibility programs, and career development
Conduct validated in vitro and in vivo assays of cells involved in angiogenesis
Provides immunodeficient and genetically modified mice for multiple in vivo HSC/HPC functional assays.
Provides flow cytometric services and genomic and proteomic analysis at the single cell level
Provides services in high resolution optical microscopy & imaging
Cell Preparation and Analysis In vitro Hematopoiesis Assays Primary Human CD34+ cells Cell Preparation and Analysis Genetic Library Service High Titer Virus Service CRISPR Service
The Imaging Core has Confocal, 2-photon STED, In vivo imaging facility – 2-photon CINEMA – spinning disk, TIRF, SIM FACS Facility: Imaging Flow Cytometer (Amnis Imagestream), PALM/STORM, STED, Automated timelapse imaging
Xenografting into Immunodeficient Mice (NSG, NSG-S, MISTRG), Humanized “BLT” Mice, Transgenic and Knockout Mice (CRISPR), Murine in vivo hematopoiesis assays, Tissue harvest and analysis service, Teaching
The Flow Cytometry Facility offers fluorescence analysis and cell sorting services
Provides state-of-the-art systems for housing, breeding, and doing experiments with zebrafish
Reprograms somatic cells into hiPSCs, performs hiPSC QC assays, and generates genomed-edited hiPSC lines
Generates gene modified mESCs and mice.
