If interested, please send CV and a cover letter with names and emails of 3 referees to Professor Yelena Ginzburg at firstname.lastname@example.org
These are exciting opportunities for several Postdoctoral Research Scientists to join the Ginzburg lab and contribute to our research. Our world class team is a senior interdisciplinary group with extensive experience in translational medicine in iron metabolism, erythropoiesis, bone homeostasis, neurophysiology and in the study of a wide range of diseases with dysregulation and these areas of biology.
The purpose of this group is to increase our knowledge of iron metabolism regulation, understand how it is dysregulated in a variety of diseases, and target these mechanisms for translational purposes.
• MD, PhD, or MD/PhD obtained after 2018 (reasonable exceptions will be made)
• Degree / experience in Genetics, Biology, Biomedicine, Biochemistry or similar
• Good CV with at least one publication as first author in important recognized research journal IF>6
• Proven experience in Genetics, Bone Biology or Iron Metabolism will be a plus
• Proven experience with animal modelling handling (mouse) will be a plus
JOB DESCRIPTION OVERVIEW:
Reporting to Prof Ginzburg, the successful candidate will function as a member of a research group for carrying out research to understand 1) the mechanistic role of erythroferrone in bone homeostasis in normal and thalassemic mice or 2) how transferrin and transferrin receptors 1 and 2 cooperate to regulate normal and β-thalassemic erythropoiesis.
The researcher will be managing either of these 2 projects, carrying out experiments independently and contributing to data analysis and interpretation. They will also, in collaboration with the lab manager/research associate, manage all the mouse colonies for Prof Ginzburg’s lab, by genotyping the animals and ensuring all breeding is carried out to meet experimental demands.
They will be responsible for running bone mineral density measurements using DEXA and microCT in mice, serumsamples to measure the level of Hepcidin, IL-6, Erythroferrone, and Erythropoietin by ELISA in mice, perform flow cytometry analyses and cell sorting as needed, measure gene expression by RT-PCR and protein concentration by western blotting and or flow cytometry in a complementary manner, and assess localization of parameters of interest using RNAScope and other microscopy methods.
They will meet with Prof Ginzburg and the group regularly to analyze and interpret the data and are expected to contribute new ideas and hypotheses to develop the project further. The post holder provides guidance to the junior lab membranes and less experienced members of the research group, including students, technicians, research assistants and postdocs.
The position is funded until 2026.