Dual training in hematology/oncology and informatics (with @nsalomonis). The lab exploits cutting-edge omics tech to answer fundamental biological questions in hematopoiesis, marrow failure and myeloid leukemia. We develop new single cell analyses and informatics tools when existing tools are insufficient to resolve the data. For example:
Mouse models of neutropenia reveal progenitor-stage-specific defects
Nature 2020 PMID: 32494068,
SKI controls MDS-associated chronic TGF-β signaling, aberrant splicing, and stem cell fitness
Blood 2018 PMID: 30249787
The Human Cell Atlas bone marrow single-cell interactive web portal
Exp Hem 2018 PMID: 30243574
Time resolved quantitative phospho-tyrosine analysis reveals Bruton's Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors
Leukemia 2019 PMID: 29977015
Single-cell analysis of mixed-lineage states leading to a binary cell fate choice
Nature 2016 PMID: 27580035.
Current projects include:
R01DK121062 “Regulation of functionally discrete hematopoietic stem cells”
R01HL122661 “Mechanisms of granulocyte homeostasis”
RC2DK122376 “A generalizable framework for linking single-cell genomic states with cell fate outcomes in hematopoiesis”
R01CA253981 “Modeling myelodysplasia in mice”
Note: We are also working to define the leukemia stem cells from three mouse models of AML, and we are working on defining the molecular causes of health disparities in the survival of AML patients with African ancestry.
Cincinnati Children's Hospital Medical Center (CCHMC) is an academic pediatric acute care children's hospital with 634 pediatric beds which serves patients from 51 countries and 50 US states. CCHMC ranks third in 2019-2020 and 2020-2021 by US News and World Report, and receives the third-most NIH funds of any pediatric institution in the United States. CCHMC’s research mission is aided by a $3 billion endowment, which subsidizes state-of-the-art core facilities with career technicians for marrow transplant, single cell processing, flow cytometry, computational biology, etc. The training environment is especially rich for hematology/oncology research because of a robust and interactive research community. CCHMC is host to the NIDDK
Cincinnati Cooperative Center of Excellence in Hematology.
Applicants must have completed a PhD in a related field, display critical and independent thinking skills, enthusiasm for science, and an ambition to succeed. Candidates should reach out to Dr. Grimes (email@example.com) with a curriculum vitae and reference contact details.