Hematopoietic Response to Stress


With the advent of single cell analyses, the classical hierarchical model of hematopoiesis is being challenged. Recent models predict that Hematopoietic Stem Cells (HSCs) are heterogeneous and that a subset is selectively favored to respond to environmental stress conditions by rapid proliferation. The purpose of the workshop is to explore data for the identity of such a “stress-response” cell and to examine how these cells invoke different pathways from those undergoing normal hematopoiesis. The molecular bases of these responses are emerging as variations on themes such as the maintenance of the integrity of the genome, post-transcriptional regulation of gene expression, changes in epitranscriptomics, alterations in subcellular organelles, and management of reactive oxygen species. This workshop aims to review the most recent progress in the field and to promote discussion of the gaps in our knowledge of these biological processes and pathways. We also expect to gain a specific understanding of the current scientific and technologic barriers to the hematology research community in the pursuit of knowledge in this area. Once these areas have been defined by the research community, representatives of the Department of Health and Human Services (HHS) can consider the most appropriate ways to try to address defined gaps.



Natcher Building 45
8600 Rockville Pike
Bethesda, MD   20894


April 29-30, 2019


John Doe
Director of Sciences

Last updated: 01-21-2020